Endothall
Product Specifications
Product Name Alternative
3,3',4,4'-Benzophenonetetracarboxylic acid
UNSPSC Description
Endothall (Endothal) is a protein phosphatase 2A (PP2A) inhibitor with IC50s of 90 nM and 5 µM for PP2A and PP1, respectively. Endothall can be used as an herbicide. Endothall also is useful in cancer chemotherapy[1].
Target Antigen
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/endothall.html
Purity
95.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC(C1C(C2CCC1O2)C(O)=O)=O
Molecular Weight
186.163
References & Citations
[1]Janetti R Signorelli, et al. Protein phosphatases decrease their activity during capacitation: a new requirement for this event. PLoS One. 2013 Dec 2;8(12):e81286.|[2]J P Thièry, et al. Hepatocellular carcinoma cell lines from diethylnitrosamine phenobarbital-treated rats. Characterization and sensitivity to endothall, a protein serine/threonine phosphatase-2A inhibitor. Hepatology. 1999 May;29(5):1406-17.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-113976A/Endothall-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-113976A/Endothall-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
145-73-3
Available Sizes
Curated Selection
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