T7 Peptide
Product Specifications
UNSPSC Description
T7 peptide is an endothelial cell-specific inhibitor. T7 peptide interacts with αVβ3 integrin to inhibit the FAK, PI3-kinase, PKB/Akt, and mTOR signaling pathways in endothelial cells, ultimately suppressing protein synthesis and inducing apoptosis[1].
Target Antigen
Apoptosis; FAK; Integrin; mTOR
Type
Peptides
Related Pathways
Apoptosis;Cytoskeleton;PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/t7-peptide.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](N)[C@@H](C)O)N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2C(C)C)=O)CC(O)=O)=O)CC(N)=O)=O)C(C)C)=O)CC(N)=O)=O)CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)CC3=CNC4=CC=CC=C34)=O)CC5=CC=C(O)C=C5)=O)CO)=O)CC6=CC=C(O)C=C6)=O)CC(O)=O)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CO)=O)C)=O)CC7=CC=CC=C7)=O)CC(N)=O)=O)=O)CC8=CC=CC=C8)=O)CC(C)C)=O)CC9=CC=CC=C9)=O)CCC1)=O)CCSC
Molecular Weight
3018.36
References & Citations
[1]Maeshima Y, et al. Tumstatin, an endothelial cell-specific inhibitor of protein synthesis. Science. 2002 Jan 4;295(5552):140-3.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P10323/T7-Peptide-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P10323/
Clinical Information
No Development Reported
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