Cyclooctyne-O-NHS ester

Cyclooctyne-O-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Cyclooctyne-O-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[1425803-45-7]

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cyclooctyne-o-nhs-ester.html

Purity

95.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(ON1C(CCC1=O)=O)COC2C#CCCCCC2

Molecular Formula

C14H17NO5

Molecular Weight

279.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Tao Wang, et al. Design and synthesis of tumor-targeting theranostic drug conjugates for SPECT and PET imaging studies. Bioorg Chem. 2018 Feb;76:458-467.