Sonepiprazole
Sonepiprazole (PNU-101387G) is a selective D4 dopamine antagonist with Kis of 3.6, 10.1, 5147, and 7430 nM for rD4-Dopamine, hD4.2-Dopamine, rD2-Dopamine, and Histamine-H1 receptors, respectively[1].
Product Specifications
CAS Number
[170858-33-0]
Product Name Alternative
PNU-101387G; U-101387G
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sonepiprazole.html
Purity
98.43
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(N2CCN(CC[C@H]3C4=CC=CC=C4CCO3)CC2)C=C1)(N)=O
Molecular Formula
C21H27N3O3S
Molecular Weight
401.52
References & Citations
[1]Mark H Corrigan, et al. Effectiveness of the selective D4 antagonist sonepiprazole in schizophrenia: a placebo-controlled trial. Biol Psychiatry. 2004 Mar 1;55 (5) :445-51.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D2 Receptor; D4 Receptor
Available Sizes
Curated Selection
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