Human ITPRIPL1 Protein, Fc Tag (MALS verified)
Inositol 1,4,5-triphosphate receptor interacting protein like 1 (ITPRIPL1) is a single transmembrane protein, exhibits normal testis-enriched expression and widespread overexpression in various human cancers. ITPRIPL1 is commonly found in tumors with low PD-L1 expression. ITPRIPL1 acts as a natural ligand for CD3 ε, evading immune surveillance, leading to decreased T cell activity and promoting tumor growth. Research has shown that inducing stable CD3E-NCK1 binding prevents CD3E-ZAP70 interaction, subsequently inhibiting downstream ERK-NFkB signaling cascade and calcium influx activation.
Product Specifications
Background
Specifications
Accession Number
Q6GPH6
Expression Region
His 25 - Gly 103
Host
HEK293
Target
ITPRIPL1
Conjugation
Unconjugated
Tag
C-Fc
Source
Human
Stability
Endotoxin
1.0 EU per μg
Purity
90%
Bioactivity
Format
Powder
Buffer
PBS, pH7.4
Additives
Trehalose
Molecular Weight
35.7 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
100ug*1
Host or Source
HEK293
Species
Human
Protein ID
Q6GPH6
Preservative
Trehalose
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
