CQ211

CQ211 is a potent and selective RIOK2 inhibitor with a Kd of 6.1 nM. CQ211 exhibits potent proliferation inhibition activity against multiple cancer cell lines[1].

Product Specifications

CAS Number

[2648986-65-4]

UNSPSC

12352005

Target

Ser/Thr Kinase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cq211.html

Purity

99.58

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C2=C(C3=CC(C4=CC=C(N=C4)OC)=CC=C3N1)N(N=N2)C5=CC=C(C(C(F)(F)F)=C5)N6CCNCC6

Molecular Formula

C26H22F3N7O2

Molecular Weight

521.49

References & Citations

[1]Ouyang Y, et al. Discovery of 8- (6-Methoxypyridin-3-yl) -1- (4- (piperazin-1-yl) -3- (trifluoromethyl) phenyl) -1,5-dihydro-4H-[1,2,3]triazolo[4,5-c]quinolin-4-one (CQ211) as a Highly Potent and Selective RIOK2 Inhibitor. J Med Chem. 2022 Jun 9;65 (11) :7833-7842.