Adenosine monophosphate-15N5 (dilithium)

Adenosine monophosphate-15N5 dilithium is the 15N labeled Adenosine monophosphate (HY-A0181) . Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction[1][2][3].

Product Specifications

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adenosine Receptor; Endogenous Metabolite; HSV; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; GPCR/G Protein; Metabolic Enzyme/Protease; Others

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/adenosine-monophosphate-15n5-dilithium.html

Concentration

100 mM in 137 μL Tris HCl/H2O buffer pH=7.5

Purity

99.22

Solubility

DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O[C@H]1[C@@H](O)[C@H]([15N]2C([15N]=C[15N]=C3[15NH2])=C3[15N]=C2)O[C@@H]1COP(O[Li])(O[Li])=O

Molecular Formula

C10H12Li2 15N5O7P

Molecular Weight

364.05

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhan Y, et al. Adenosine 5'-monophosphate ameliorates D-galactosamine/lipopolysaccharide-induced liver injury through an adenosine receptor-independent mechanism in mice. Cell Death Dis. 2014 Jan 9;5:e985. |[2]Rittiner JE, et al. AMP is an adenosine A1 receptor agonist. J Biol Chem. 2012 Feb 17;287 (8) :5301-9. |[3]Ayisi NK, et al. Comparison of the antiviral effects of 5-methoxymethyldeoxyuridine-5'-monophosphate with adenine arabinoside-5'-monophosphate. Antiviral Res. 1983 Sep;3 (3) :161-74.