3-Chloro-5-hydroxybenzoic acid
3-Chloro-5-hydroxybenzoic acid is a potent, orally active and selective lactate receptor GPR81 agonist, with an EC50 of 16 μM for human GPR81. 3-Chloro-5-hydroxybenzoic acid exhibits favorable in vivo effects on lipolysis in a mouse model of obesity[1].
Product Specifications
CAS Number
53984-36-4
UNSPSC
12352005
Hazard Statement
H302, H315, H318, H335
Target
Hydroxycarboxylic Acid Receptor (HCAR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/3-chloro-5-hydroxybenzoic-acid.html
Concentration
10mM
Purity
99.54
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=CC(O)=CC(C(O)=O)=C1
Molecular Formula
C7H5ClO3
Molecular Weight
172.57
Precautions
H302, H315, H318, H335
References & Citations
[1]Dvorak CA, et al. Identification of Hydroxybenzoic Acids as Selective Lactate Receptor (GPR81) Agonists with Antilipolytic Effects. ACS Med Chem Lett. 2012;3 (8) :637-639. Published 2012 Jun 11.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HCAR1
Available Sizes
Frequently Asked Questions
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