YHO-13351
YHO-13351 is the prodrug of YHO-13177, which is a potent and specific inhibitor of BCRP.
Product Specifications
CAS Number
[1346753-00-1]
UNSPSC
12352005
Target
BCRP
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/YHO-13351.html
Concentration
10mM
Purity
99.16
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
N#C/C(C1=CC=C(OC)C(OC)=C1)=C\C2=CC=C(N3CCC(OC(CN(CC)CC)=O)CC3)S2.O=S(C)(O)=O
Molecular Formula
C27H37N3O7S2
Molecular Weight
579.73
References & Citations
[1]Yamazaki R, et al. Novel acrylonitrile derivatives, YHO-13177 and YHO-13351, reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo. Mol Cancer Ther. 2011 Jul;10 (7) :1252-63.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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