α-Synuclein aggregate binder 1

α-Synuclein aggregate binder 1 (Compound C05-05) is a specific binder for α-synuclein aggregates and can inhibit α-synuclein aggregation. α-Synuclein aggregate binder 1 can be used as a fluorescent probe (excitation wavelength 900 nm, detection wavelength 500-550 nm) for optical imaging, and can also inhibit α-synuclein fibril formation by blocking the aggregation process. α-Synuclein aggregate binder 1 can be used for positron emission tomography (PET) imaging after being labeled with 18F. α-Synuclein aggregate binder 1 can be used for visual diagnosis of brain lesions and mechanism research of neurodegenerative diseases such as Parkinson's disease and Lewy body dementia[1][2].

Product Specifications

CAS Number

[1565797-17-2]

UNSPSC

12352005

Target

Fluorescent Dye; Radionuclide-Drug Conjugates (RDCs) ; α-synuclein

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Neuronal Signaling; Others

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/α-synuclein-aggregate-binder-1.html

Purity

98.11

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CNC1=NC=C(C=C1)C#C/C=C/C(SC2=C3)=NC2=CC=C3OCC(O)CF

Molecular Formula

C20H18FN3O2S

Molecular Weight

383.44

References & Citations

[1]Higuchi M, et al., Novel α-synuclein aggregate binding agents for disease diagnosis using optical imaging. WO2020174963.|[2]Preparation of novel but-1-en-3-yne compound, α-synuclein aggregate binder, and use thereof. World Intellectual Property Organization, WO2023163033 A1. 2023-08-31.