σ1 Receptor antagonist-1
σ1 Receptor antagonist-1 is a highly potent and selective sigma 1 receptor antagonist (pKi=10.28) . σ1 Receptor antagonist-1 inhibits cell growth, arrests cell cycle at G0/G1 phase and induces apoptosis of MCF-7/ADR cells[1].
Product Specifications
CAS Number
[1204401-49-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Sigma Receptor
Type
Reference compound
Related Pathways
Apoptosis; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/σ1-receptor-antagonist-1.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1CC(C2CCN(CC3=CC=CC=C3)CC2)SC4=CC=CC=C41
Molecular Formula
C21H23NOS
Molecular Weight
337.48
Precautions
H302, H315, H319, H335
References & Citations
[1]Piergentili A, et al. Novel highly potent and selective sigma 1 receptor antagonists related to spipethiane. J Med Chem. 2010;53 (3) :1261-1269.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Sigma 1 Receptor
Available Sizes
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