Thymine-d4-1
Thymine-d4-1 is the deuterium labeled Thymine[1]. Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM[2].
Product Specifications
CAS Number
156054-85-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer
Purity
99.47
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C(C([2H])([2H])[2H])=C([2H])NC(N1)=O
Molecular Formula
C5H2D4N2O2
Molecular Weight
130.14
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Tuchman M, et al. Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase. Cancer Res. 1985 Nov;45 (11 Pt 1) :5553-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
K4523202 1.0 µg DNA
Meis2 sgRNA CRISPR Lentivector (Mouse) (Target 1)
Sign In for Pricing
View Details 
![CAMK2B Mouse Monoclonal Antibody [Clone ID: OTI10G2]](https://cdn.genprice.uk/products/937/68dd18b9061270361e9082f3/imageurl/cf808346.webp)
CF808346 100 µg
CAMK2B Mouse Monoclonal Antibody [Clone ID: OTI10G2]
Sign In for Pricing
View Details ![Mouse TLR3 Matched Antibody Pair Set [ABP-S-04679]](https://cdn.genprice.uk/genprice/uk/genprice3.webp)
ABP-S-04679 5 Plates
Mouse TLR3 Matched Antibody Pair Set [ABP-S-04679]
Sign In for Pricing
View Details