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NFh-ALP

NFh-ALP is an alkaline phosphatase (ALP) -activatable photosensitizer. NFh-ALP could be activated by ALP in cells and generate 1O2 under 808 nm excitation, effectively killing tumor cells by inducing apoptosis and having good biocompatibility. The maximum absorption wavelength of NFh-ALP is about 656 nm[1].

Product Specifications

UNSPSC

12352005

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nfh-alp.html

Smiles

CC1(C)C(/C=C/C(CCC2)=C3C2=CC(C=C(Br)C(OP(O)(O)=O)=C4)=C4O3)=[N+](CC)C5=CC=C(Br)C=C15.[I-]

Molecular Formula

C27H27Br2INO5P

Molecular Weight

763.19

References & Citations

[1]Chao Zhao, et al. Alkaline Phosphatase Activated Near-Infrared Frequency Upconversion Photosensitizers for Tumor Photodynamic Therapy. J Med Chem. 2024 Aug 8;67 (15) :13383-13391.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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