RO-28-1675

RO-28-1675 is a potent allosteric glucokinase (GK) activator with an EC50 of 54 nM. RO-28-1675 can be used for the research of type 2 diabetes[1][2].

Product Specifications

CAS Number

[300353-13-3]

UNSPSC

12352005

Target

Glucokinase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Ro_28-1675.html

Purity

99.89

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C([C@@H](C1=CC=C(C=C1)S(=O)(C)=O)CC2CCCC2)NC3=NC=CS3

Molecular Formula

C18H22N2O3S2

Molecular Weight

378.51

References & Citations

[1]Joseph Grimsby, et al. Allosteric activators of glucokinase: potential role in diabetes therapy. Science. 2003 Jul 18;301 (5631) :370-3.|[2]Nancy-Ellen Haynes, et al. Discovery, structure-activity relationships, pharmacokinetics, and efficacy of glucokinase activator (2R) -3-cyclopentyl-2- (4-methanesulfonylphenyl) -N-thiazol-2-yl-propionamide (RO0281675) . J Med Chem. 2010 May 13;53 (9) :3618-25.