Capravirine
Capravirine (S-1153) is an orally active non-nucleoside reverse transcriptase inhibitor (NNRTI) with potent antiviral activity. Capravirine inhibits replication of HIV-1 strains that are resistant to nucleoside/nucleotide reverse transcriptase inhibitors and other NNRTIs. Capravirine is metabolized by the cytochrome P450 enzyme CYP3A4[1][2].
Product Specifications
CAS Number
178979-85-6
Product Name Alternative
S-1153
UNSPSC
12352005
Target
HIV; Reverse Transcriptase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/capravirine.html
Smiles
O=C(N)OCC1=NC(C(C)C)=C(N1CC2=CC=NC=C2)SC3=CC(Cl)=CC(Cl)=C3
Molecular Formula
C20H20Cl2N4O2S
Molecular Weight
451.37
References & Citations
[1]Bu HZ, et al. Metabolism and excretion of capravirine, a new non-nucleoside reverse transcriptase inhibitor, alone and in combination with ritonavir in healthy volunteers. Drug Metab Dispos. 2004 Jul;32 (7) :689-98.|[2]Gewurz BE, et al. Capravirine, a nonnucleoside reverse-transcriptase inhibitor in patients infected with HIV-1: a phase 1 study. J Infect Dis. 2004 Dec 1;190 (11) :1957-61.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
425521-01 25 mg
3-Fluoro-2- (tetramethyl-1,3,2-dioxaborolan-2-yl) benzonitrile
Sign In for Pricing
View Details 425521-02 50 mg
3-Fluoro-2- (tetramethyl-1,3,2-dioxaborolan-2-yl) benzonitrile
Sign In for Pricing
View Details