α-Casozepine
α-Casozepine is a bioactive peptide derived from the α protein S1 casein in milk and has an affinity for γ-aminobutyric acid (GABA) receptors in the brain. α-Casozepine has anti-anxiety effects[1][2].
Product Specifications
CAS Number
117592-45-7
UNSPSC
12352209
Target
GABA Receptor
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/α-casozepine.html
Purity
99.36
Solubility
DMSO : 20 mg/mL (ultrasonic; warming) |H2O : 66.67 mg/mL (ultrasonic; adjust pH to 2 with 1 M HCl)
Smiles
OC(C=C1)=CC=C1C[C@H](NC(CNC([C@H](CC(C)C)NC([C@@H](N)CC2=CC=C(C=C2)O)=O)=O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O
Molecular Formula
C60H94N14O16
Molecular Weight
1267.47
References & Citations
[1]Miclo L, et al. Characterization of alpha-casozepine, a tryptic peptide from bovine alpha (s1) -casein with benzodiazepine-like activity. FASEB J. 2001 Aug;15 (10) :1780-2.|[2]Landsberg G, et al Therapeutic effects of an alpha-casozepine and L-tryptophan supplemented diet on fear and anxiety in the cat. J Feline Med Surg. 2017 Jun;19 (6) :594-602.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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