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α-Casozepine

α-Casozepine is a bioactive peptide derived from the α protein S1 casein in milk and has an affinity for γ-aminobutyric acid (GABA) receptors in the brain. α-Casozepine has anti-anxiety effects[1][2].

Product Specifications

CAS Number

[117592-45-7]

UNSPSC

12352209

Target

GABA Receptor

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/α-casozepine.html

Purity

99.36

Solubility

DMSO : 20 mg/mL (ultrasonic; warming) |H2O : 66.67 mg/mL (ultrasonic; adjust pH to 2 with 1 M HCl)

Smiles

OC(C=C1)=CC=C1C[C@H](NC(CNC([C@H](CC(C)C)NC([C@@H](N)CC2=CC=C(C=C2)O)=O)=O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O

Molecular Formula

C60H94N14O16

Molecular Weight

1267.47

References & Citations

[1]Miclo L, et al. Characterization of alpha-casozepine, a tryptic peptide from bovine alpha (s1) -casein with benzodiazepine-like activity. FASEB J. 2001 Aug;15 (10) :1780-2.|[2]Landsberg G, et al Therapeutic effects of an alpha-casozepine and L-tryptophan supplemented diet on fear and anxiety in the cat. J Feline Med Surg. 2017 Jun;19 (6) :594-602.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-P2602/α-Casozepine-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-P2602/α-Casozepine-SDS-MedChemExpress.pdf

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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