Lass1
Product Specifications
Background
LAG1 is a longevity gene, the first such gene to be identified. Originally cloned from the yeast Saccharomyces cerevisiae. A close homolog of this gene, LAC1, has been found in the yeast genome. The Human homolog of LAG1 has functions in Human aging. LAG1 may be involved in neurodegenerative diseases and Human aging. Lass1 may be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner. Located in the endoplasmic reticulum membrane; LAss1 is a multi-pass membrane protein.
Synonyms
LAG1 longevity assurance homolog 1, UOG-1 Protein, LAG1, LASS1
UniProt
P27544 (Human)
Species Reactivity
Human
Conjugation
Unconjugated
Type
Blocking Peptide
Applications
WB
Field of Research
Lipid Mediators
Assay Principle
For use with Lass1 polyclonal antibodies (Cat. No. X2083P , X2311P).
Stability
See expiration date on vial
Concentration
See vial for Concentration
Form
Provided as solution in phosphate buffered saline with 0,08% sodium azide
Precautions
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
Shipping Conditions
Ambient Temperature, freeze upon arrival
Storage Conditions
Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
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