Obtustatin

Obtustatin is a non-RGD disintegrin of 41 residues. Obtustatin can be isolated from Vipera lebetina obtusa venom. Obtustatin is a potent and selective inhibitor of the adhesion of integrin α1β1 to collagen IV. Obtustatin inhibits angiogenesis, and can be used for research of cancer[1][2].

Product Specifications

CAS Number

[404882-00-4]

UNSPSC

12352209

Target

Integrin

Type

Peptides

Related Pathways

Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/obtustatin.html

Purity

99.69

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@@H](N)CSSC[C@H](NC1=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]3CC4=CC=C(O)C=C4)=O)CC5=CNC=N5)=O)CO)=O)[C@@H](C)O)=O)CC(C)C)=O)CO)=O)[C@@H](C)O)=O)CCCCN)=O)CC6=CNC7=CC=CC=C67)=O)CSSC[C@H](NC8=O)C(N9[C@H](C(N[C@H](C(N[C@H](C(N%10[C@H](C(NCC(O)=O)=O)CCC%10)=O)CC%11=CC=C(O)C=C%11)=O)CC(C)C)=O)CCC9)=O)=O)[C@@H](C)O)=O)[C@@H](C)O)=O)=O)C)=O)CCC2)=O)CCCCN)=O)CC(C)C)=O)CCCCN)=O)N[C@H](C(N[C@H](C(NCC(N%12[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CCC(N)=O)=O)CCCNC(N)=N)=O)CSSC[C@H](NC%13=O)C(N[C@H]8CC(O)=O)=O)=O)CSSC[C@H](NC3=O)C(N[C@H](C(NCC(NC(C(NC%13CO)=O)CCCCN)=O)=O)[C@@H](C)O)=O)=O)CCC%12)=O)=O)[C@@H](C)O)=O)[C@@H](C)O

Molecular Formula

C184H284N52O57S8

Molecular Weight

4393.06

References & Citations

[1]Paz Moreno-Murciano M, et al. NMR solution structure of the non-RGD disintegrin obtustatin. J Mol Biol. 2003 May 23;329 (1) :135-45.|[2]Marcinkiewicz C, et al. Obtustatin: a potent selective inhibitor of alpha1beta1 integrin in vitro and angiogenesis in vivo. Cancer Res. 2003 May 1;63 (9) :2020-3.