Naltriben
Naltriben is a selective δ2-opioid receptor antagonist and TRPM7 activator. Naltriben enhances glioblastoma cell migration and invasion. Naltriben can be used in research into neurological diseases and cancer[1][2].
Product Specifications
CAS Number
111555-58-9
UNSPSC
12352005
Target
Opioid Receptor; TRP Channel
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/naltriben.html
Solubility
10 mM in DMSO
Smiles
O[C@@]1(CC(C(C=CC=C2)=C2O3)=C3[C@]4([H])OC5=C6O)[C@]74C5=C(C=C6)C[C@@]1([H])N(CC8CC8)CC7
Molecular Formula
C26H25NO4
Molecular Weight
415.48
References & Citations
[1]Lever JR, et al. Selective in vivo binding of [3H]naltriben to delta-opioid receptors in mouse brain. Eur J Pharmacol. 1998 Jun 5;350 (2-3) :335-44.|[2]Wong R, et al. Activation of TRPM7 by naltriben enhances migration and invasion of glioblastoma cells. Oncotarget. 2017 Feb 14;8 (7) :11239-11248.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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