Exendin(9-39) amide
Product Specifications
UNSPSC Description
Exendin(9-39) amide (Avexitide) is a glucagon-like peptide-1 (GLP-1) antagonist that competes with endogenous GLP-1 for binding to GLP-1 receptors, thereby antagonizing the effects of excess GLP-1 secretion. Exendin(9-39) amide can be used to study postoperative hypoglycemia (PBH)[1].
Target Antigen
GLP Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Exendin_9-39.html
Purity
99.81
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
C([C@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(O)=O)N)=O)CC(C)C)=O)CO)=O)CCCCN)=O)CCC(N)=O)=O)CCSC)=O)CCC(O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)C)=O)[C@H](C)C)=O)CCCNC(=N)N)=O)CC(C)C)=O)=O)[C@H](CC)C)=O)CCC(O)=O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(=O)N2[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(=O)N3[C@H](C(=O)N4[C@H](C(=O)N5[C@H](C(N[C@H](C(N)=O)CO)=O)CCC5)CCC4)CCC3)C)=O)=O)CO)=O)CO)=O)CCC2)=O)=O)CC(N)=O)=O)CCCCN)=O)CC(C)C)=O)C=6C=7C(NC6)=CC=CC7
Molecular Weight
3369.76
References & Citations
[1]Calabria AC, et al. GLP-1 receptor antagonist exendin-(9-39) elevates fasting blood glucose levels in congenital owing to inactivating mutations in the ATP-sensitive K+ channel. Diabetes. 2012 Oct;61(10):2585-91.|[2]De León DD, et al. Exendin-(9-39) corrects fasting hypoglycemia in SUR-1-/- mice by lowering cAMP in pancreatic beta-cells and inhibiting secretion. J Biol Chem. 2008 Sep 19;283(38):25786-93.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P0264/Exendin-9-39-amide-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P0264/Exendin-9-39-amide-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
133514-43-9
Available Sizes
Curated Selection
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