Alovudine
Alovudine (3'-Fluoro-3'-deoxythymidine) is a mtDNA synthesis inhibitor and a marker of DNA synthesis. Alovudine is less susceptible to inflammatory changes than 18F-Fluorodeoxyglucose (FDG) and thus is a better biomarker in pancreatic cancer. Alovudine shows anti-orthopoxvirus and anti-leukemic activity[1][2][3][4][5][6].
Product Specifications
CAS Number
[25526-93-6]
Product Name Alternative
3'-Fluoro-3'-deoxythymidine; 3′-Deoxy-3′-fluorothymidine; FLT
UNSPSC
12352005
Hazard Statement
H315, H319
Target
DNA/RNA Synthesis; Orthopoxvirus
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/alovudine.html
Purity
99.88
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 25 mg/mL
Smiles
OC[C@@H]1[C@@H](F)C[C@H](N2C(NC(C(C)=C2)=O)=O)O1
Molecular Formula
C10H13FN2O4
Molecular Weight
244.22
Precautions
H315, H319
References & Citations
18
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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