PIP4K-IN-a131
PIP4K-IN-a131 is PIP4K lipid kinases inhibitor, with IC50s of 1.9 μM and 0.6 μM for purified PIP4K2A and PIP4Ks, respectively. PIP4K-IN-a131 exhibits cancer-selective lethality via dual blockade of the lipid kinase PIP4Ks and mitotic pathways[1].
Product Specifications
CAS Number
[2055405-95-1]
UNSPSC
12352005
Target
PI5P4K
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pip4k-in-a131.html
Purity
99.42
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
N#C/C(C1=CNC2=C1C=CC=C2)=C\C3=CC=CC4=C3C=CN=C4
Molecular Formula
C20H13N3
Molecular Weight
295.34
References & Citations
[1]Mayumi Kitagawa, et al. Dual Blockade of the Lipid Kinase PIP4Ks and Mitotic Pathways Leads to Cancer-Selective Lethality. Nat Commun. 2017 Dec 19;8 (1) :2200.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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