BNS-22
Product Specifications
UNSPSC Description
BNS-22 is a DNA topoisomerase II (TOP2) catalytic inhibitor with the IC50 values of 2.8 μM and 0.42 μM for human TOP2α and TOP2β, respectively. BNS-22 induces abnormal division and has anti-proliferative activity[1].
Target Antigen
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bns-22.html
Solubility
10 mM in DMSO
Smiles
O=C1C=C(CCC)C2=C(OC)C=C(OC)C(C(N3CCCC4=C3C=CC=C4)=O)=C2O1
Molecular Weight
407.46
References & Citations
[1]Makoto Kawatani, et al. Identification of a small-molecule inhibitor of DNA topoisomerase II by proteomic profiling. Chem Biol. 2011 Jun 24;18(6):743-51.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-122594/BNS-22-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-122594/
Clinical Information
No Development Reported
CAS Number
1151668-24-4
Available Sizes
Curated Selection
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