BNS-22

BNS-22 is a DNA topoisomerase II (TOP2) catalytic inhibitor with the IC50 values of 2.8 μM and 0.42 μM for human TOP2α and TOP2β, respectively. BNS-22 induces abnormal division and has anti-proliferative activity[1].

Product Specifications

CAS Number

[1151668-24-4]

UNSPSC

12352005

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bns-22.html

Purity

99.50

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C=C(CCC)C2=C(OC)C=C(OC)C(C(N3CCCC4=C3C=CC=C4)=O)=C2O1

Molecular Formula

C24H25NO5

Molecular Weight

407.46

References & Citations

[1]Makoto Kawatani, et al. Identification of a small-molecule inhibitor of DNA topoisomerase II by proteomic profiling. Chem Biol. 2011 Jun 24;18 (6) :743-51.