APS6-45
APS6-45 is an orally active tumor-calibrated inhibitor (TCI) . APS6-45 inhibits RAS/MAPK signaling and exhibits antitumor activity[1].
Product Specifications
CAS Number
2188236-41-9
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aps6-45.html
Purity
99.58
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C1=NC=CC(OC2=CC=C(C=C2)NC(NC3=CC(C(F)(C(F)(F)F)C(F)(F)F)=CC=C3F)=O)=C1)NC
Molecular Formula
C23H16F8N4O3
Molecular Weight
548.39
References & Citations
[1]Sonoshita M, et, al. A whole-animal platform to advance a clinical kinase inhibitor into new disease space. Nat Chem Biol. 2018 Mar;14 (3) :291-298.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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