MCTR3
MCTR3 is a potent cytokine of pro-resolving mediating maresin conjugates in tissue regeneration (MCTR), which reduces the inflammatory response and promotes the tissue regeneration. MCTR3 exhibits potency in ameliorating LPS-induced acute lung injury and arthritis[1][2][3].
Product Specifications
CAS Number
1784701-63-8
UNSPSC
12352211
Hazard Statement
H225, H319
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Others
Assay Protocol
https://www.medchemexpress.com/mctr3.html
Concentration
215.69 μM * 100 μL in Ethanol)
Purity
98.40
Solubility
10 mM in DMSO
Smiles
O[C@H]([C@@H](/C=C/C=C/C=C\C/C=C\CCC(O)=O)SC[C@@H](C(O)=O)N)C/C=C\C/C=C\CC
Molecular Formula
C25H37NO5S
Molecular Weight
463.63
Precautions
H225, H319
References & Citations
[1]Zhuang R, et al., MCTR3 reduces LPS-induced acute lung injury in mice via the ALX/PINK1 signaling pathway. Int Immunopharmacol. 2021 Jan;90:107142.|[2]Dalli J et al., Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3. PLoS One. 2016 Feb 16;11 (2) :e0149319.|[3]Pistorius K, et al., MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis. EBioMedicine. 2022 May;79:103974.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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