MCTR3

MCTR3 is a potent cytokine of pro-resolving mediating maresin conjugates in tissue regeneration (MCTR), which reduces the inflammatory response and promotes the tissue regeneration. MCTR3 exhibits potency in ameliorating LPS-induced acute lung injury and arthritis[1][2][3].

Product Specifications

CAS Number

[1784701-63-8]

UNSPSC

12352211

Hazard Statement

H225, H319

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Others

Assay Protocol

https://www.medchemexpress.com/mctr3.html

Concentration

215.69 μM * 100 μL in Ethanol)

Purity

98.40

Solubility

10 mM in DMSO

Smiles

O[C@H]([C@@H](/C=C/C=C/C=C\C/C=C\CCC(O)=O)SC[C@@H](C(O)=O)N)C/C=C\C/C=C\CC

Molecular Formula

C25H37NO5S

Molecular Weight

463.63

Precautions

H225, H319

References & Citations

[1]Zhuang R, et al., MCTR3 reduces LPS-induced acute lung injury in mice via the ALX/PINK1 signaling pathway. Int Immunopharmacol. 2021 Jan;90:107142.|[2]Dalli J et al., Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3. PLoS One. 2016 Feb 16;11 (2) :e0149319.|[3]Pistorius K, et al., MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis. EBioMedicine. 2022 May;79:103974.