STING-IN-4

STING-IN-4 (Compound 1) is a STING inhibitor that inhibits STING expression and hence reducing activation of STING and nuclear factor-κB (NF-κB) signaling. STING-IN-4 shows anti-inflammatory activity and can be used for the research of sepsis[1].

Product Specifications

CAS Number

[2250374-27-5]

UNSPSC

12352005

Target

STING

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sting-in-4.html

Purity

99.87

Solubility

DMSO : 93.33 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@]3([H])[C@]([C@]4(C([C@@]5([H])[C@@](CC4)(CCC(C)(C5)C)C(O)=O)=CC3)C)(CC[C@@]1([H])[C@@](C)(C6=NC=CN=C6C2)CO)C

Molecular Formula

C32H46N2O3

Molecular Weight

506.72

References & Citations

[1]Yu T, et al. Design and synthesis of hederagenin derivatives modulating STING/NF-κB signaling for the relief of acute liver injury in septic mice. Eur J Med Chem. 2023 Jan 5;245 (Pt 1) :114911.