Romazarit

Romazarit (RO 31-3948) is an anti-inflammatory agent with antirheumatic effect. Romazarit exhibits PPARα agonist activity. Romazarit (30 mg/kg) inhibits the development of hindpaw inflammation in an adjuvant arthritis model[1][2][3].

Product Specifications

CAS Number

109543-76-2

Product Name Alternative

RO 31-3948

UNSPSC

12352005

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/romazarit.html

Smiles

CC(C)(OCC1=C(C)N=C(C2=CC=C(Cl)C=C2)O1)C(O)=O

Molecular Formula

C15H16ClNO4

Molecular Weight

309.74

References & Citations

[1]Bloxham DP, et al. Biologic properties of romazarit (Ro 31-3948), a potential disease-modifying antirheumatic drug. J Pharmacol Exp Ther. 1990 Mar;252 (3) :1331-40.|[2]Pillai AD, et al. Tetra substituted thiophenes as anti-inflammatory agents: exploitation of analogue-based drug design. Bioorg Med Chem. 2005 Dec 15;13 (24) :6685-92. |[3]Clary Clish, et al. Romazarit for treating metabolic diseases. WO2010014771A1.