Retinoic acid-d3-1

Retinoic acid-d3-1 is the deuterium labeled Retinoic acid (HY-14649) . Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[1][2][3].

Product Specifications

CAS Number

[3041101-53-2]

Product Name Alternative

Vitamin A acid-d3-1; all-trans-Retinoic acid-d3-1; ATRA-d3-1

UNSPSC

12352211

Target

Autophagy; Endogenous Metabolite; Isotope-Labeled Compounds; PPAR; RAR/RXR

Type

Isotope-Labeled Compounds

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer; Metabolic Disease

Smiles

CC(/C=C/C1=C(CCCC(C)1C)C)=C\C=C\C(C([2H])([2H])[2H])=C\C(O)=O

Molecular Formula

C20H25D3O2

Molecular Weight

303.45

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Wu L, et al. Retinoid X Receptor Agonists Upregulate Genes Responsible for the Biosynthesis of All-Trans-Retinoic Acid in Human Epidermis. PLoS One. 2016 Apr 14;11 (4) :e0153556.|[3]Shaw N, et al. Retinoic acid is a high affinity selective ligand for the peroxisome proliferator-activated receptor beta/delta. J Biol Chem. 2003 Oct 24;278 (43) :41589-92.