Yohimbine (Hydrochloride)
Product Specifications
UNSPSC Description
Yohimbine hydrochloride is an alpha-2 renal adenomatase receptor inhibitor, blocking pre- and post-contact alpha-2 renal adenomatase receptors, causing the release of renal adenoma and multiple sclerosis.
Target Antigen
Adrenergic Receptor
Type
Natural Products
Related Pathways
GPCR/G Protein;Neuronal Signaling
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/Yohimbine-Hydrochloride.html
Purity
99.91
Solubility
DMSO : 8.75 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 3.33 mg/mL (ultrasonic)
Smiles
[H][C@]12C(NC3=C4C=CC=C3)=C4CCN1C[C@@]5(CC[C@H](O)[C@H](C(OC)=O)[C@]5(C2)[H])[H].[H]Cl
Molecular Weight
390.90
References & Citations
[1]Docherty JR, et al. Yohimbine antagonises α1A- and α1D-adrenoceptor mediated components in addition to the α2A-adrenoceptor component to pressor responses in the pithed rat. Eur J Pharmacol. 2012 Mar 15;679(1-3):90-4.|[2]Docherty JR. Yohimbine antagonises α1A- and α1D-adrenoceptor mediated components in addition to the α2A-adrenoceptor component to pressor responses in the pithed rat. Eur J Pharmacol. 2012 Mar 15;679(1-3):90-4.|[3]Damase-Michel C, et al. The effect of yohimbine on sympathetic responsiveness in essential hypertension. Eur J Clin Pharmacol. 1993;44(2):199-201.|[4]Musso NR, et al. Yohimbine effects on blood pressure and plasma catecholamines in human hypertension. Am J Hypertens. 1995 Jun;8(6):565-71. |[5]Sáiz J, et al. Yohimbine-induced alterations in alpha(2)-adrenoceptors in kidney regions of the spontaneously hypertensive rats: an autoradiographic analysis. Pharmacol Rep. 2008 May-Jun;60(3):391-8.Eur J Pharmacol. 2023 Nov 6:176174.|Exp Neurobiol. 2020 Oct 31;29(5):356-375.|Mol Biol Rep. 2020 May;47(5):3629-3639.|Mol Med Rep. 2020 Jul;22(1):175-184.|Neurosci Bull. 2022 Apr;38(4):386-402.|Biomed Pharmacother. 2022 Apr 26;150:113006.|Drug Des Devel Ther. 2024 Apr 9:18:1103-1114.|Eur J Neurosci. 2021 Nov 4.|J Neuroinflammation. 2022 May 27;19(1):123.|J Neurophysiol. 2023 Apr 12.|Research Square Preprint. 2023 Dec 16.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N0127/Yohimbine-Hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N0127/Yohimbine-Hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
65-19-0
Available Sizes
Curated Selection
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