Yohimbine (Hydrochloride)

Yohimbine hydrochloride is an alpha-2 renal adenomatase receptor inhibitor, blocking pre- and post-contact alpha-2 renal adenomatase receptors, causing the release of renal adenoma and multiple sclerosis.

Product Specifications

CAS Number

[65-19-0]

UNSPSC

12352005

Hazard Statement

H300, H311+H331

Target

Adrenergic Receptor

Type

Natural Products

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/Yohimbine-Hydrochloride.html

Purity

99.92

Solubility

DMSO : 8.75 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 3.33 mg/mL (ultrasonic)

Smiles

[H][C@]12C(NC3=C4C=CC=C3)=C4CCN1C[C@@]5(CC[C@H](O)[C@H](C(OC)=O)[C@]5(C2)[H])[H].[H]Cl

Molecular Formula

C21H27ClN2O3

Molecular Weight

390.90

Precautions

H300, H311+H331

References & Citations

[1]Docherty JR, et al. Yohimbine antagonises α1A- and α1D-adrenoceptor mediated components in addition to the α2A-adrenoceptor component to pressor responses in the pithed rat. Eur J Pharmacol. 2012 Mar 15;679 (1-3) :90-4.|[2]Docherty JR. Yohimbine antagonises α1A- and α1D-adrenoceptor mediated components in addition to the α2A-adrenoceptor component to pressor responses in the pithed rat. Eur J Pharmacol. 2012 Mar 15;679 (1-3) :90-4.|[3]Damase-Michel C, et al. The effect of yohimbine on sympathetic responsiveness in essential hypertension. Eur J Clin Pharmacol. 1993;44 (2) :199-201.|[4]Musso NR, et al. Yohimbine effects on blood pressure and plasma catecholamines in human hypertension. Am J Hypertens. 1995 Jun;8 (6) :565-71. |[5]Sáiz J, et al. Yohimbine-induced alterations in alpha (2) -adrenoceptors in kidney regions of the spontaneously hypertensive rats: an autoradiographic analysis. Pharmacol Rep. 2008 May-Jun;60 (3) :391-8.