KKL-40
Product Specifications
Product Name Alternative
Hydroxytolbutamide
UNSPSC Description
KKL-40 is a small molecule inhibitor that targets the trans-transcription process and is effective against methicillin-sensitive and -resistant Staphylococcus aureus (S. aureus) as well as other Gram-positive pathogens including vancomycin-resistant Enterococcus faecium, Bacillus subtilis, and Streptococcus pyogenes. KKL-40 synergizes with the human antimicrobial peptide LL-37 to inhibit S. aureus, but does not synergize with other antibiotics such as daptomycin, kanamycin, or erythromycin. Trans-transcription is an extreme form of recoding, and KKL-40 inhibits trans-transcription but is nontoxic to HeLa cells[1].
Target Antigen
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/kkl-40.html
Purity
95.70
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(NC1=NN=C(C2=CC=C(F)C=C2)O1)C3=CC=CC(C(F)(F)F)=C3
Molecular Weight
351.26
References & Citations
[1]A Small Molecule Inhibitor of Trans -Translation Synergistically Interacts with Cathelicidin Antimicrobial Peptides to Impair Survival of Staphylococcus aureus.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-116863/KKL-40-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-116863/KKL-40-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
865285-47-8
Available Sizes
Curated Selection
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