22 (R) -Hydroxycholesterol

22 (R) -Hydroxycholesterol (Narthesterol) is an endogenous LXR agonist. 22 (R) -Hydroxycholesterol (Narthesterol) can be used for tangier disease research[1].

Product Specifications

CAS Number

[17954-98-2]

Product Name Alternative

Narthesterol

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

LXR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/22-r-hydroxycholesterol.html

Purity

99.86

Solubility

Ethanol : ≥ 100 mg/mL

Smiles

O[C@@H](CC[C@@]12C)CC1=CC[C@@]3([C@@]2(CC[C@]4([C@]3(CC[C@]4([H])[C@H](C)[C@@H](CCC(C)C)O)[H])C)[H])[H]

Molecular Formula

C27H46O2

Molecular Weight

402.65

Precautions

H302, H315, H319, H335

References & Citations

[1]Costet P, et al. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J Biol Chem. 2000 Sep 8;275 (36) :28240-5.