Norfloxacin

Norfloxacin (MK-0366) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase.

Product Specifications

CAS Number

[70458-96-7]

Product Name Alternative

MK-0366

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial; Endogenous Metabolite

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Norfloxacin.html

Purity

99.0

Solubility

DMSO : 5 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C(C1=CN(CC)C2=C(C=C(F)C(N3CCNCC3)=C2)C1=O)O

Molecular Formula

C16H18FN3O3

Molecular Weight

319.33

Precautions

H302, H315, H319, H335

References & Citations

[1]Nelson JM, et al. Fluoroquinolone-resistant Campylobacter species and the withdrawal of fluoroquinolones from use in poultry: a public health success story. Clin Infect Dis. 2007 Apr 1;44 (7) :977-80. Epub 2007 Feb 14.|[2]Pade?skaia EN. Norfloxacin: more than 20 years of clinical use, the results and place among fluoroquinolones in modern chemotherapy for infections. Antibiot Khimioter. 2003;48 (9) :28-36.|[3]Rafalsky V, et al. Quinolones for uncomplicated acute cystitis in women. Cochrane Database Syst Rev. 2006 Jul 19; (3) :CD003597.