AEG3482

AEG3482 is a potent antiapoptotic compound that inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70) . AEG3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25[1].

Product Specifications

CAS Number

[63735-71-7]

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; JNK

Type

Reference compound

Related Pathways

Apoptosis; MAPK/ERK Pathway

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/aeg3482.html

Purity

99.79

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=S(C1=NN2C(S1)=NC(C3=CC=CC=C3)=C2)(N)=O

Molecular Formula

C10H8N4O2S2

Molecular Weight

280.33

Precautions

H302

References & Citations

[1]Salehi AH, et, al. AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70. Chem Biol. 2006 Feb;13 (2) :213-23.