AEG3482
AEG3482 is a potent antiapoptotic compound that inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70) . AEG3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25[1].
Product Specifications
CAS Number
[63735-71-7]
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; JNK
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/aeg3482.html
Purity
99.79
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=S(C1=NN2C(S1)=NC(C3=CC=CC=C3)=C2)(N)=O
Molecular Formula
C10H8N4O2S2
Molecular Weight
280.33
Precautions
H302
References & Citations
[1]Salehi AH, et, al. AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70. Chem Biol. 2006 Feb;13 (2) :213-23.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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