UFP-512
Product Specifications
UNSPSC Description
UFP-512 is a selective and potent σ-opioid receptor (DOP receptor) peptidic agonist with antidepressant- and anxiolytic-like effects. UFP-512 exhibits as a potent agonist on adenylyl cyclase inhibition and Erk1/2 activation. UFP-512 induces phosphorylation of DOP receptors on Ser363 with a low desensitization of the cAMP pathway. UFP-512 is promising for research of mood disorders[1].
Target Antigen
Adenylate Cyclase; ERK; Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;MAPK/ERK Pathway;Neuronal Signaling;Stem Cell/Wnt
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ufp-512.html
Smiles
CC(C=C(C=C1C)O)=C1C[C@H](N)C(N2[C@@H](CC3=CC=CC=C3C2)C(N[C@H](C4=NC5=CC=CC=C5N4)CC(O)=O)=O)=O
Molecular Weight
555.62
References & Citations
[1]Aguila B, et al. In vitro and in vivo pharmacological profile of UFP-512, a novel selective delta-opioid receptor agonist; correlations between desensitization and tolerance. Br J Pharmacol. 2007 Dec;152(8):1312-24.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-130176/UFP-512-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-130176/
Clinical Information
No Development Reported
CAS Number
480446-44-4
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