UFP-512

UFP-512 is a selective and potent σ-opioid receptor (DOP receptor) peptidic agonist with antidepressant- and anxiolytic-like effects. UFP-512 exhibits as a potent agonist on adenylyl cyclase inhibition and Erk1/2 activation. UFP-512 induces phosphorylation of DOP receptors on Ser363 with a low desensitization of the cAMP pathway. UFP-512 is promising for research of mood disorders[1].

Product Specifications

CAS Number

[480446-44-4]

UNSPSC

12352005

Target

Adenylate Cyclase; ERK; Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; Neuronal Signaling; Stem Cell/Wnt

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ufp-512.html

Smiles

CC(C=C(C=C1C)O)=C1C[C@H](N)C(N2[C@@H](CC3=CC=CC=C3C2)C(N[C@H](C4=NC5=CC=CC=C5N4)CC(O)=O)=O)=O

Molecular Formula

C31H33N5O5

Molecular Weight

555.62

References & Citations

[1]Aguila B, et al. In vitro and in vivo pharmacological profile of UFP-512, a novel selective delta-opioid receptor agonist; correlations between desensitization and tolerance. Br J Pharmacol. 2007 Dec;152 (8) :1312-24.