SIRT1 activator 1

SIRT1 activator 1 (compound 3) is a derivative of marine compound xyloallenoide A isolated from the mangrove fungus Xylaria sp.SIRT1 activator 1 shows angiogenic activities in zebrafish. SIRT1 activator 1 protects hEPC against AngII-induced senescence by increasing SIRT1 expression levels and balancing the AMPK/Akt signaling pathway[1].

Product Specifications

UNSPSC

12352211

Target

Sirtuin

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sirt1-activator-1.html

Solubility

10 mM in DMSO

Smiles

C[C@@H](NC([C@@H](NC([C@H](N)C(C)C)=O)CCCCNC(OC(C)(C)C)=O)=O)C(O)=O

Molecular Formula

C19H36N4O6

Molecular Weight

416.51

References & Citations

[1]Jing Yang, et al. Marine Compound Exerts Antiaging Effect in Human Endothelial Progenitor Cells via Increasing Sirtuin1 Expression. ACS Pharmacol. Transl. Sci. Publication Date:October 10, 2023