Garetosmab

Garetosmab (REGN 2477) is a fully human IgG4 monoclonal antibody that specifically inhibits activin A. Garetosmab can be used for fibrodysplasia ossificans progressiva (FOP) research[1].

Product Specifications

CAS Number

[2097125-54-5]

Product Name Alternative

REGN 2477

UNSPSC

12352203

Target

TGF-β Receptor

Type

Inhibitory Antibodies

Related Pathways

TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/garetosmab.html

Purity

99.57

Solubility

10 mM in DMSO

Smiles

[Garetosmab]

Molecular Weight

(145.52 kDa)

References & Citations

[1]Frédéric Vanhoutte, et al. Pharmacokinetics and Pharmacodynamics of Garetosmab (Anti-Activin A) : Results From a First-in-Human Phase 1 Study. J Clin Pharmacol. 2020 Nov;60 (11) :1424-1431.