(±) 13-HDHA

(±) 13-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Fresh water hydra is shown to metabolize DHA to 13 (R) -HDHA, presumably via the 11R-lipoxygenase activity. (±) 13-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.

Product Specifications

CAS Number

[90780-53-3]

Product Name Alternative

(±) 13-HDoHE; 13-hydroxy Docosahexaenoic acid; (±) 13-HDoHE

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Lipoxygenase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/racemic-13-hdha.html

Concentration

317.97 μM * 500 μL in Ethanol

Purity

98.8

Smiles

CCC/C=C\C/C=C\C/C=C\CC(/C=C/C=C/C/C=C\CC)O

Molecular Formula

C22H34O

Molecular Weight

314.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Di Marzo, et al. Polyunsaturated-fatty-acid oxidation in Hydra: Regioselectivity, substrate-dependent enantioselectivity and possible biological role. Biochem. J. 300, 501-507 (1994) .