PA-915

PA-915 (PAC1R antagonist 1) (compound 3d) is a potent and orally active antagonist of PAC1 receptor. PAC1R antagonist 1 can inhibit pituitary adenylate cyclase-activating polypeptide (PACAP) - and nerve injury-induced allodynia[1].

Product Specifications

CAS Number

[2305204-24-2]

Product Name Alternative

PAC1R antagonist 1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PACAP Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pac1r-antagonist-1.html

Concentration

10mM

Purity

99.17

Solubility

DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 160°C)

Smiles

O=C(C1CC(N(C1)C2=NNC3=C2C=CC=C3Cl)=O)NCCC4=CNC=N4

Molecular Formula

C17H17ClN6O2

Molecular Weight

372.81

Precautions

H302, H315, H319, H335

References & Citations

[1]Takasaki I, et, al. Synthesis of a novel and potent small-molecule antagonist of PAC1 receptor for the treatment of neuropathic pain. Eur J Med Chem. 2020 Jan 15;186:111902.