Mersalyl
Mersalyl (Salirgan) is a potent vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 (HIF-1) inducer. Mersalyl induces VEGF and ENO1 mRNA expression. Mersalyl shows diuresis effects[1][2][3].
Product Specifications
CAS Number
492-18-2
Product Name Alternative
Salirgan; Salurin; Salyrgan
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase; VEGFR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/mersalyl.html
Purity
89.25
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
[O-]C(COC1=C(C(NCC2OC)=[O][Hg+2]([CH2-]2)[OH-])C=CC=C1)=O.[Na+]
Molecular Formula
C13H16HgNNaO6
Molecular Weight
505.85
References & Citations
[1]Kowaltowski AJ, et al. Mitochondrial membrane protein thiol reactivity with N-ethylmaleimide or mersalyl is modified by Ca2+: correlation with mitochondrial permeability transition. Biochim Biophys Acta. 1997 Feb 15;1318 (3) :395-402.|[2]Agani F, et al. Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity. Mol Pharmacol. 1998 Nov;54 (5) :749-54.|[3]FARAH A, et al. Histochemical studies on the site of action of mercurial diuretics. J Histochem Cytochem. 1955 Jul;3 (4) :271-3.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
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