Mersalyl

Mersalyl (Salirgan) is a potent vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 (HIF-1) inducer. Mersalyl induces VEGF and ENO1 mRNA expression. Mersalyl shows diuresis effects[1][2][3].

Product Specifications

CAS Number

[492-18-2]

Product Name Alternative

Salirgan; Salurin; Salyrgan

UNSPSC

12352005

Target

HIF/HIF Prolyl-Hydroxylase; VEGFR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/mersalyl.html

Purity

89.25

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

[O-]C(COC1=C(C(NCC2OC)=[O][Hg+2]([CH2-]2)[OH-])C=CC=C1)=O.[Na+]

Molecular Formula

C13H16HgNNaO6

Molecular Weight

505.85

References & Citations

[1]Kowaltowski AJ, et al. Mitochondrial membrane protein thiol reactivity with N-ethylmaleimide or mersalyl is modified by Ca2+: correlation with mitochondrial permeability transition. Biochim Biophys Acta. 1997 Feb 15;1318 (3) :395-402.|[2]Agani F, et al. Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity. Mol Pharmacol. 1998 Nov;54 (5) :749-54.|[3]FARAH A, et al. Histochemical studies on the site of action of mercurial diuretics. J Histochem Cytochem. 1955 Jul;3 (4) :271-3.