AZD9898
AZD9898 is an orally active leukotriene-C4 synthetase (LTC4S, glutathione S-transferase II) inhibitor, with an IC50 of 0.28 nM. AZD9898 mitigates the GABA binding and hepatic toxicity signal. AZD9898 has the potential to treat asthma[1].
Product Specifications
CAS Number
2042347-69-1
UNSPSC
12352005
Target
Glutathione S-transferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/azd9898.html
Purity
98.01
Solubility
DMSO : ≥ 250 mg/mL
Smiles
O=C([C@@H]1[C@@H](C(C2=NC=C(N(C3=CC(Cl)=C(F)C=C3F)CC(C)(F)C)N=C2OC)=O)C1)O
Molecular Formula
C20H19ClF3N3O4
Molecular Weight
457.83
References & Citations
[1]Munck Af Rosenschöld M, et al. Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S) -2- ({5-[ (5-Chloro-2,4-difluorophenyl) (2-fluoro-2-methylpropyl) amino]-3-methoxypyrazin-2-yl}carbonyl) cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma. J Med Chem. 2019 Aug 30.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
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