Santamarine
Santamarine (Santamarin), a sesquiterpene lactone, increases HO-1 expression through Nrf2 translocation and suppresses NO, PGE2, TNF-α, and IL-1β production through inhibition of NF-κB translocation in LPS-induced macrophages. Santamarine shows anti-photoaging properties via inhibition of MAPK/AP-1 and stimulation of TGF-β/Smad signaling in UVA-irradiated human dermal fibroblasts (HDFs) . Antioxidant activities[1][2].
Product Specifications
CAS Number
[4290-13-5]
Product Name Alternative
Santamarin; Balchanin
UNSPSC
12352005
Target
Keap1-Nrf2
Type
Natural Products
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/santamarine.html
Purity
98.85
Solubility
10 mM in DMSO
Smiles
O=C(O[C@@]1([H])[C@@]2([H])CC[C@@]3(C)[C@H](O)CC=C(C)[C@@]31[H])C2=C
Molecular Formula
C15H20O3
Molecular Weight
248.32
References & Citations
Saussurea lappa
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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