Stressin I (TFA)
Stressin I (Cyclo (31-34) [DPhe12, Nle21,38, Glu31, Lys34]Ac-hCRF (4-41) ) TFA is a potent CRF1 receptor selective agonist, Ki is 1.7 nM. Stressin I induces an increase in adrenocorticotropic hormone (ACTH) levels in rats[1][1].
Product Specifications
Product Name Alternative
Cyclo (31-34) [DPhe12, Nle21,38, Glu31, Lys34]Ac-hCRF (4-41) (TFA)
UNSPSC
12352209
Target
CRFR
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/stressin-i-tfa.html
Purity
98.63
Solubility
H2O : 1.98 mg/mL (ultrasonic; adjust pH to 3 with HCl)
Smiles
CCCC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CCC(NCCCC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)CCC(O)=O)=O)CCCC)=O)CC(C)C)=O)CCCCN)=O)CCCNC(N)=N)=O)NC([C@@H](NC([C@@H](NC1=O)CC2=CNC=N2)=O)CO)=O)=O)=O)CCC(N)=O)=O)CCC(N)=O)=O)C)=O)CC(C)C)=O)CCC(N)=O)=O)CCC(O)=O)=O)C)=O)CCCNC(N)=N)=O)C)=O)NC([C@@H](NC([C@@H](NC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@H]([C@H](O)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@H](CC)C)NC([C@@H]3CCCN3C([C@@H]4CCCN4C(C)=O)=O)=O)=O)CO)=O)CC(C)C)=O)CC(O)=O)=O)CC(C)C)=O)=O)CC5=CC=CC=C5)=O)CC6=CNC=N6)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCC(O)=O)=O)=O)CC(C)C)=O)CCC(O)=O)=O.xOC(C(F)(F)F)=O
Molecular Formula
C203H337N57O56.xC2HF3O2
Molecular Weight
4472.20 (free base)
References & Citations
[1]Rivier J, et al. Stressin1-A, a potent corticotropin releasing factor receptor 1 (CRF1) -selective peptide agonist. J Med Chem. 2007 Apr 5;50 (7) :1668-74. [Content Brief]
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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