Dopamine-d5 (hydrochloride)

Dopamine-d5 (hydrochloride) is the deuterium labeled Dopamine (hydrochloride) . Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body[1]. Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis[1].

Product Specifications

CAS Number

[2193106-55-5]

Product Name Alternative

ASL279-d5 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Dopamine Receptor; Endogenous Metabolite; Ferroptosis; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Purity

99.6

Solubility

H2O : 50 mg/mL (ultrasonic; warming)

Smiles

NCC([2H])([2H])C1=C([2H])C(O)=C(C([2H])=C1[2H])O.Cl

Molecular Formula

C8H7D5ClNO2

Molecular Weight

194.67

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Juárez Olguín H, et al. The Role of Dopamine and Its Dysfunction as a Consequence of Oxidative Stress. Oxid Med Cell Longev. 2016;2016:9730467.|[3]Basu S, et al. The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor. Nat Med. 2001 May;7 (5) :569-74.