PF-05180999
PF-05180999 (PF-999) is a phosphodiesterase 2A (PDE2A) inhibitor, with an IC50 of 1.6 nM.
Product Specifications
CAS Number
1394033-54-5
Product Name Alternative
PF-999
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H335
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/PF-05180999.html
Purity
99.97
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC1=NC(C2=C(C3=CC=C(C(F)(F)F)C=N3)N(C)N=C2)=C4N1N=CN=C4N5CCC5
Molecular Formula
C19H17F3N8
Molecular Weight
414.39
Precautions
H301, H315, H319, H335
References & Citations
[1]Helal CJ, et al. Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate. J Med Chem. 2018 Feb 8;61 (3) :1001-1018.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
PDE10; PDE11; PDE2; PDE7
Available Sizes
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